It is crucial to obtain adequate amounts of vitamin D on daily basis, as deficiency can lead to a host of health issues. Vitamin D3 and Vitamin K2 are essential micronutrients with ubiquitous roles throughout the body, such as supporting stress levels, bone health, skin health, heart health, and immune function. These findings indicate that combined administration of vitamin D 3 and vitamin K 2, compared with calcium administration, appears to be useful in increasing the BMD of the lumbar spine in postmenopausal women with osteoporosis.D3 5000 with K2 is a highly bioavailable form of Vitamin D3-as cholecalciferol-and vitamin K2-as patented MenaQ7®. Two-way ANOVA with repeated measurements showed a significant increase in BMD in the D and K groups compared with that in the C group ( P < 0.05 and P < 0.001, respectively), and a significant increase in BMD in the DK group compared with that in the C, D, and K groups ( P < 0.0001, P < 0.05 and P < 0.01, respectively). One-way analysis of variance (ANOVA) with repeated measurements showed a significant decrease in BMD in the C group ( P < 0.001).

There were no significant differences in age, body mass index, years since menopause, and initial BMD among the four groups.

BMD of the lumbar spine (L2–L4) was measured by dual energy X-ray absorptiometry at 0, 1, and 2 years after the treatment started. Ninety-two osteoporotic women who were more than 5 years after menopause, aged 55–81 years, were randomly divided into four administration groups: vitamin D 3 (1α hydroxyvitamin D 3, 0.75 μg/day) (D group n = 29), vitamin K 2 (menatetrenone, 45 mg/day) (K group n = 22), vitamin D 3 plus vitamin K 2 (DK group, n = 21), and calcium (calcium lactate, 2 g/day) (C group n = 20).

The effect of the combined administration of vitamin D 3 and vitamin K 2 on bone mineral density (BMD) of the lumbar spine was examined in postmenopausal women with osteoporosis.

Download vitamin d and k2